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meropenem side effects

meropenem side effects

Many patients in these trials were severely ill and had multiple background diseases, physiological impairments and were receiving multiple other drug therapies. mL/min). Amropenem (500 mg) 500mg - 1 Vial Injection (Meropenem) drug information. Pneumonia Vaccination: Who Should Have One? Common side effects of Merrem IV include injection site pain and inflammation, rash, constipation, diarrhea, nausea, vomiting, and headache. Serious side effects of Merrem IV include. Satisfactory bacteriologic response was 80% in the meropenem group and 75% in the imipenem/cilastatin group. CLINICAL PHARMACOLOGY]. greater than 0.1% of the patients are listed below within each body system in order of decreasing frequency: Body as a Whole: pain, abdominal pain, chest pain, fever, back pain, abdominal enlargement, chills, pelvic pain, Cardiovascular: heart failure, heart arrest, tachycardia, hypertension, myocardial infarction, pulmonary embolus, Enterovirulent Escherichia coli (E. coli) are strains of related bacteria that have a strong propensity to cause gastrointestinal tract infections. During clinical investigations, 2904 immunocompetent adult patients were treated for non-CNS infections with MERREM IV (500 mg or 1 gram every 8 hours). Pediatric Patients with Serious Bacterial Infections (excluding Bacterial Meningitis): Merrem IV was studied in 515 pediatric patients (3 months to less than 13 years of age) with serious bacterial infections (excluding meningitis, see next section) at dosages of 10 mg/kg to 20 mg/kg every 8 hours. When taking Merrem (meropenem), you might experience stiff muscles or abnormal muscle movements. Common side effects include nausea, diarrhea, constipation, headache, rash, and pain at the site of injection. If any of these effects last or get worse, tell your doctor or pharmacist promptly. It is not known whether this drug is excreted in human milk. One patient treated with imipenem/cilastatin experienced a seizure during the study, while another patient treated with meropenem withdrew due to urticaria. The meropenem group had a statistically higher number of patients with transient elevation of liver enzymes. Take the Pneumonia Quiz on MedicineNet to learn more about this highly contagious, infectious disease. Symptoms include fever, headache, and a stiff neck. Increased levels of Merrem IV in the body could increase side effects like nausea, vomiting, and headache. The meropenem group had a statistically higher number of patients with transient elevation of liver enzymes. Increased levels of meropenem in the body could increase side effects like nausea, vomiting, and headache. The adverse reactions seen in these patients that were reported and their rates of occurrence are as follows: Adverse Laboratory Changes in Pediatric Patients. The adverse reactions seen in these patients that were reported and their rates of occurrence are as follows: Adverse Laboratory Changes in Pediatric Patients. greater than 0.1% of the patients are listed below within each body system in order of decreasing frequency: Bleeding events were seen as follows: gastrointestinal hemorrhage (0.5%), melena (0.3%), epistaxis (0.2%), Merrem IV was studied in 200 neonates and infants less than 3 months of age. MedicineNet does not provide medical advice, diagnosis or treatment. If administration of The following adverse reactions have been identified during post-approval use of MERREM IV. Merrem is used in the treatment of infections of the abdomen, such as appendicitis and peritonitis, bacterial meningitis (infection of the lining of the brain), and skin infections. Blood And Lymphatic System Disorders: agranulocytosis, neutropenia, and leukopenia; a positive direct or indirect Coombs test, and hemolytic anemia. The study was open-label, uncontrolled, 98% of the infants received concomitant medications, and the majority of adverse events were reported in neonates less than 32 weeks gestational age and critically ill at baseline, making it difficult to assess the relationship of the adverse events to Our Merrem IV Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication. Pneumonia is inflammation of the lungs caused by fungi, bacteria, or viruses. Merrem IV. Read the entire FDA prescribing information for Merrem IV (Meropenem). Upset stomach, headache, nausea, vomiting, constipation, or diarrhea may also occur. Merrem (meropenem) may make you feel weak or confused. Complications of E. coli infection include hemorrhagic diarrhea, hemolytic-uremic syndrome, and thrombotic thrombocytopenic purpura. decreasing the serum concentrations of valproic acid. Meningitis is inflammation of the membranes that cover the spinal cord and brain. E. coli can cause urinary tract and bladder infections, or lead to sepsis. Laboratory changes seen in the pediatric studies, including the meningitis studies, were similar to those reported in the adult studies. Probenecid may increase levels of Merrem IV by reducing its elimination through the kidneys. Although not all of these side effects may occur, if they do occur they may need medical attention. leukocytosis, hypokalemia, Renal: increased creatinine and increased blood urea nitrogen (BUN). Pneumonia may be contagious for 2-14 days. It should be used during pregnancy only if clearly needed. In case of a severe side effect or reaction, call the doctor, nurse or pharmacist at 595-3300. About how much does an adult human brain weigh? Get our free fact sheet. E coli O157:H7 (EHEC) causes bloody diarrhea and colitis. Upset stomach , headache , nausea , vomiting , constipation , or diarrhea may also occur. Adverse Reactions. Worldwide post-marketing adverse reactions not otherwise listed in the Adverse Reactions from Clinical Trials section of this prescribing information and reported as possibly, probably, or definitely drug related are listed within each body system in order of decreasing severity. There are five types of meningitis: viral, bacterial, fungal, parasitic, and noninfectious. You may report side effects to FDA at 1-800-FDA-1088. If it affects one lung, it is termed single pneumonia. Headache 5. Drug interactions of Merrem IV include valproic acid or divalproex because Merrem IV may reduce absorption of valproic acid and divalproex from the intestine and increase elimination of the drugs through the kidneys thereby reducing the levels of these drugs in the body and reducing their effectiveness. You are encouraged to report negative side effects of prescription drugs to the FDA. The types of systemic and local adverse events seen in these patients are similar to the adults, with the most common adverse reactions reported as possibly, probably, or definitely related to MERREM IV and their rates of occurrence as follows: In the meningitis studies, the rates of seizure activity during therapy were comparable between patients with no CNS abnormalities who received meropenem and those who received comparator agents (either cefotaxime or ceftriaxone). In the seriously ill patient population, it was not possible to determine the relationship between observed adverse events and therapy with Merrem IV. Side effects of Merrem include: Merrem IV (meropenem) is an antibiotic used to treat certain types of bacterial infections. Complicated Skin and Skin Structure Infections Bacteria cannot survive without a cell wall. Symptoms may vary depending on the strain the individual contracts. intestinal obstruction, Hemic/Lymphatic: anemia, hypochromic anemia, hypervolemia, Metabolic/Nutritional: peripheral edema, hypoxia, Nervous System: insomnia, agitation, delirium, confusion, dizziness, seizure, nervousness, paresthesia, hallucinations, Black or tarry stools. Mild pneumonia may be healed by body’s defense system. Copyright © 2020 by RxList Inc. RxList does not provide medical advice, diagnosis or treatment. View Meropenem’s uses, side-effects, drug interactions, expert advice and user FAQs only on 1mg.com. Many patients in these trials were severely ill and had multiple background diseases, physiological impairments and were receiving multiple other drug therapies. hematocrit, decreased white blood cell (WBC), shortened prothrombin time and shortened partial thromboplastin time, Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure. Meropenem Side Effects: Common, Severe, Long Term - Drugs.com Complicated Skin and Skin Structure Infections MERREM IV. Latest Infectious Disease News Ticks Jumping From Dogs to Humans Meropenem may cause serious allergic reactions, including anaphylaxis, which can be life-threatening and requires immediate medical attention. valproic acid's glucuronide metabolite (VPA-g) back to valproic acid, thus If it affects only a certain lobe of a lung it's termed lobar pneumonia. The following adverse reaction frequencies were derived from the clinical trials in the 2904 patients treated with Merrem IV (meropenem) is an antibiotic used to treat certain types of bacterial infections. Adverse effects. Common side effects of Merrem IV include injection site pain and inflammation, rash, constipation, diarrhea, nausea, vomiting, and headache. drugs a-z list If … It is administered intravenously. Pill Identifier Tool Quick, Easy, Pill Identification, Drug Interaction Tool Check Potential Drug Interactions, Pharmacy Locater Tool Including 24 Hour, Pharmacies. It kills bacteria that are resistant to other antibiotics. Meningitis is an inflammation of the membrane (meninges) surrounding the brain and spinal cord and is characterized by an abnormal number of white blood cells in the cerebrospinal fluid. Tell your doctor or nurse right away if you or your child have itching, hives, hoarseness, trouble breathing, trouble swallowing, or any swelling of your hands, face, or mouth after receiving this medicine. species. Decreased urine output. Most people who take Merrem (meropenem) usually have few side effects. In the seriously ill patient population, it was not possible to determine the relationship between observed adverse events and therapy with MERREM IV. severe stomach pain, diarrhea that is watery or bloody; sores or white patches in your mouth or throat (yeast infection or "thrush"); nausea, vomiting, diarrhea, constipation; Risk of Breakthrough Seizures Due to Drug Interaction with Valproic Acid [see, Clostridium difficile – associated Diarrhea [see, Development of Drug-Resistant Bacteria [see, Overgrowth of Nonsusceptible Organisms [see. Read the entire detailed patient monograph for Merrem IV (Meropenem). Adequate and well-controlled studies of this drug in pregnant women are lacking, and this drug should be used during pregnancy only if clearly needed. Tell your doctor if any of these symptoms are severe or do not go away: headache; diarrhea; nausea; redness, pain, or swelling at the injection site; burning or tingling in the hands or feet; confusion; Some side effects can be serious. It’s good at treating severe and complicated bacterial infections. Meropenem is used in the treatment of Severe bacterial infections. The following are discussed in greater detail in other sections of labeling: Because clinical trials are conducted under widely varying conditions, adverse reactions rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice. In the Merrem IV treated group, 12/15 patients with seizures had late onset seizures (defined as occurring on day 3 or later) versus 7/20 in the comparator arm. Risk of Breakthrough Seizures Due to Drug Interaction with Valproic Acid. Blood And Lymphatic System Disorders: agranulocytosis, neutropenia, and leukopenia; a positive direct or indirect Coombs test, and hemolytic anemia. hematocrit, decreased white blood cell (WBC), shortened prothrombin time and shortened partial thromboplastin time, Shortness of breath. Check with your doctor or nurse immediately if any of the following side effects occur: Less common. What drugs interact with Merrem IV (meropenem injection)? E coli O157:H7 commonly is due to eating raw or undercooked hamburger or raw milk or dairy products. severe diarrhea (watery or bloody stools) that may occur with or without fever and stomach cramps (may occur up to 2 months or more after your treatment) hives. Deaths in 5 patients were assessed as possibly related to meropenem; 36 (1.2%) patients had meropenem discontinued because of adverse events. A Skin Rash 2. bradycardia, hypotension, syncope, Digestive System: oral moniliasis, anorexia, cholestatic jaundice/jaundice, flatulence, ileus, hepatic failure, dyspepsia, Safe and effective use of Merrem IV is not established in pregnant females. See additional information. dehydrogenase (LDH), and bilirubin, Hematologic: increased platelets, increased eosinophils, decreased platelets, decreased hemoglobin, decreased Anemia If experienced, these tend to have a Less Severe expression 1. Merrem (meropenem) is available as a generic. Bacterial Infections 101 Pictures Slideshow, E. coli 0157:H7 (Escherichia coli 0157:H7), E. Coli Outbreaks in Potato Salad and Wading Pool. and animal studies suggest that carbapenems may inhibit the hydrolysis of Digestive Disorders: Common Misconceptions. Meropenem can also affect your neurological (brain) function, which can cause dizziness, fainting, or seizures. diarrhea (4.8%), nausea/vomiting (3.6%), headache (2.3%), rash (1.9%), sepsis (1.6%), constipation (1.4%), apnea Below is a summary of known side effects for MERREM IV. MERREM IV. Merrem IV (meropenem injection) side effects list for healthcare professionals. Merrem IV is effective against susceptible strains of E. coli, H. influenzae, K. pneumoniae, N. meningitidis, P. aeruginosa, and many other bacteria. Side Effects Swelling, redness, pain, or soreness at the injection site may occur. What is meningitis and what causes it? It is administered intravenously. soreness, redness, or swelling at the injection site. Probenecid competes with meropenem for active tubular secretion, resulting in increased plasma concentrations of meropenem. Serious adverse effects are rare. Adverse laboratory changes that were reported and occurring in greater than 0.2% of the patients were as follows: Hepatic: increased alanine transaminase (ALT), aspartate transaminase (AST), alkaline phosphatase, lactate Fast heartbeat. Symptoms may include: skin rash, fever, swollen glands, muscle aches, severe weakness, unusual bruising, or yellowing of your skin or eyes. MERREM IV was studied in 200 neonates and infants less than 3 months of age. Background: Drug-induced immune thrombocytopenia (DITP) is a serious, life-threatening clinical syndrome, the diagnosis of which is consistently difficult. Adverse events with an incidence of greater than 1%, and not listed above, include: pharyngitis, accidental injury, gastrointestinal disorder, hypoglycemia, peripheral vascular disorder, and pneumonia. bradycardia, hypotension, syncope, Digestive System: oral moniliasis, anorexia, cholestatic jaundice/jaundice, flatulence, ileus, hepatic failure, dyspepsia, Like most antibacterials, it is common to have diarrhea when taking this medicine. (Meropenem) side effects drug center, Pharmacy Editor: Melissa Conrad Stöppler, MD. Merrem IV (meropenem injection) is a carbapenem antibiotic used to treat a variety of bacteria, including E. coli, H. influenzae, K. pneumoniae, N. meningitidis, P. aeruginosa, and others. E. coli spreads from person to person via contaminated food or Merrem IV. Probenecid (Benemid) may increase levels of meropenem by reducing its elimination through the kidneys. Safe and effective use of Merrem IV is not established in pregnant females. The walls are necessary to protect bacteria from their environment and to keep the contents of the bacterial cell together. Case reports in the literature have shown that co-administration of carbapenems, including meropenem, to patients receiving valproic acid or divalproex sodium results in a reduction in valproic acid concentrations. Vomiting patients with moderately severe renal impairment (creatinine clearance 10 to 26 Swelling and redness at the injection site. … Infection is spread generally through contaminated food or drink. chills. Symptoms and signs of E. coli infection include diarrhea, stomach cramps, and sometimes fever. Antibiotics treat E. coli infection. Adverse laboratory changes that were reported and occurring in greater than 0.2% of the patients were as follows: Hepatic: increased alanine transaminase (ALT), aspartate transaminase (AST), alkaline phosphatase, lactate However severe cases of pneumonia require medical attention especially viral pneumonia. Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning in your eyes, skin pain, red or purple … Pneumonia is inflammation of the lung usually caused by bacterial or viral infection (rarely, also by fungi) that causes the air sacs to fill with pus. By continuing to browse this site you are agreeing to our use of cookies. Swelling at the injection site. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure. Meninges act as a protective layer to the brain and spinal cord. Skin rash. Worldwide post-marketing adverse reactions not otherwise listed in the Adverse Reactions from Clinical Trials section of this prescribing information and reported as possibly, probably, or definitely drug related are listed within each body system in order of decreasing severity. Learn how to use Meropenem, and it's dosage, warnings, side-effects, and more. Upset stomach, headache, nausea, vomiting, constipation, or diarrhea may also occur. Abdominal pain. seizure, nervousness, paresthesia, hallucinations, somnolence, anxiety, MERREM IV was studied in 321 pediatric patients (3 months to less than 17 years of age) with meningitis at a dosage of 40 mg/kg every 8 hours. depression, asthenia, Respiratory: respiratory disorder, dyspnea, pleural effusion, asthma, cough increased, lung edema, Skin and Appendages: urticaria, sweating, skin ulcer, Urogenital System: dysuria, kidney failure, vaginal moniliasis, urinary incontinence. confusion. Co-administration of meropenem IV with valproic acid or divalproex sodium reduces serum concentrations of valproic acid potentially increasing risk of breakthrough seizures. If you experience any of these symptoms, stop using meropenem injection and call your doctor immediately or get emergency medical treatment: seizures. Safe and effective use of Merrem IV is not established in pregnant females. Constipation 3. If inflammation affects both lungs, the infection is termed double pneumonia. Copyright © 2018 by RxList Inc. RxList does not provide medical advice, diagnosis or treatment. The valproic acid concentrations may drop below the therapeutic range as a result of this interaction, therefore increasing the risk of breakthrough seizures. Skin reactions. Fever. Should I Get the Pneumonia Vaccine Every Year? Indications, dose, contra-indications, side-effects, interactions, cautions, warnings and other safety information for MEROPENEM. 1. home/medications health center/medications a-z list/side effects of meropenem-injection article. Meropenem Side Effects Swelling, redness, pain, or soreness at the injection site may occur. A severe and sometimes deadly reaction has happened. Examples of strains include: EHEC (enterohemorrhagic E. coli), ETEC (enterotoxigenic E. coli), EPEC (enteropathogenic E. coli), EIEC (enteroinvasive E. coli), EAEC (enteroadherent E. coli), and EAggEC (enteroaggregative E. coli). Although the mechanism of this interaction is unknown, data from in vitro Merrem I.V. See additional information. Meropenem Side Effects Swelling, redness, pain, or soreness at the injection site may occur. somnolence, anxiety, depression, asthenia [see WARNINGS AND PRECAUTIONS], Respiratory: respiratory disorder, dyspnea, pleural effusion, asthma, cough increased, lung edema, Skin and Appendages: urticaria, sweating, skin ulcer, Urogenital System: dysuria, kidney failure, vaginal moniliasis, urinary incontinence. What are the important side effects of Merrem IV (meropenem injection)? Pneumonia can be deadly. Side Effects for MERREM IV (meropenem injection) are also known as adverse reactions. Visit the FDA MedWatch website or call 1-800-FDA-1088. Skin And Subcutaneous Disorders: Stevens-Johnson syndrome, toxic epidermal necrolysis, drug reaction with eosinophilia and systemic symptoms (DRESS), erythema multiforme and acute generalized exanthematous pustulosis. 6 Several studies have indicated that the most important factor governing the neurotoxicity of a carbapenem is the concentration achieved in the brain tissue. Meropenem is used for complicated skin and soft tissue infection, complicated infections occurring within the stomach cavity, inflammation of the brain and spinal cord membranes (bacterial meningitis), or infection during or following childbirth (intra or post-partum infections). intestinal obstruction, Hemic/Lymphatic: anemia, hypochromic anemia, hypervolemia, Metabolic/Nutritional: peripheral edema, hypoxia, Nervous System: insomnia, agitation, delirium, confusion, dizziness, Usually, the goal of medications given for pneumonia is to limit the spread of the disease. Laboratory changes seen in the pediatric studies, including the meningitis studies, were similar to those reported in the adult studies. Common side effects of meropenem include diarrhea, nausea and vomiting, and headache. hemoperitoneum (0.2%). During clinical investigations, 2904 immunocompetent adult patients were treated for non-CNS infections with Merrem IV (500 mg or 1 gram every 8 hours). Merrem IV (meropenem injection) is a carbapenem antibiotic used to treat a variety of bacteria. These may be encountered; Pain at the site of injection. The following adverse reaction frequencies were derived from the clinical trials in the 2904 patients treated with The study was open-label, uncontrolled, 98% of the infants received concomitant medications, and the majority of adverse events were reported in neonates less than 32 weeks gestational age and critically ill at baseline, making it difficult to assess the relationship of the adverse events to Additional systemic adverse events that were reported with Merrem IV and occurring in less than or equal to 1.0% but Meningitis, inflammation of the meninges, symptoms and signs include neck stiffness, headache, and fever. Major & minor side effects for Meropenem. Diarrhea. If experienced, these tend to have a Severe expression 1. Use in pregnancy appears to be safe. In this report, we present a case of DITP caused by meropenem that was confirmed by laboratory tests. In the MERREM IV treated group, 12/15 patients with seizures had late onset seizures (defined as occurring on day 3 or later) versus 7/20 in the comparator arm. Deaths in 5 patients were assessed as possibly related to meropenem; 36 (1.2%) patients had meropenem discontinued because of adverse events. Additional systemic adverse events that were reported with MERREM IV and occurring in less than or equal to 1.0% but The following adverse reactions have been identified during post-approval use of Merrem IV. Confusion. Symptoms and signs include cough, fever, shortness of breath, and chills. Most of the time, this reaction has signs like fever, rash, or swollen glands with problems in body organs like the liver, kidney, blood, heart, muscles and joints, or lungs. Terms of Use. Does Merrem IV (meropenem injection) cause side effects? Most pneumonias are caused by bacteria and viruses, but some pneumonias are caused by inhaling toxic chemicals that damage lung tissue. Merrem IV is necessary, then supplemental anti-convulsant therapy should be Systemic adverse events that were reported with MERREM IV occurring in greater than 1.0% of the patients were diarrhea (4.8%), nausea/vomiting (3.6%), headache (2.3%), rash (1.9%), sepsis (1.6%), constipation (1.4%), apnea (1.3%), shock (1.2%), and pruritus (1.2%). The most common adverse events occurring in greater than 5% of the patients were: headache (7.8%), nausea (7.8%), constipation (7.0%), diarrhea (7.0%), anemia (5.5%), and pain (5.1%). See additional information. Indications, dose, contra-indications, side-effects, interactions, cautions, warnings and other safety information for MEROPENEM. Imipenem and panipenem, which are carbapenems with a relatively high tendency to produce neurotoxicity, have basic C-2 side chains while meropenem's side chain is much less basic. The types of systemic and local adverse events seen in these patients are similar to the adults, with the most common adverse reactions reported as possibly, probably, or definitely related to Merrem IV and their rates of occurrence as follows: In the meningitis studies, the rates of seizure activity during therapy were comparable between patients with no CNS abnormalities who received meropenem and those who received comparator agents (either cefotaxime or ceftriaxone). Bluish lips or skin 2. chills 3. cold, clammy skin 4. confusion 5. dizziness 6. fainting 7. fast heartbeat 8. fast, weak pulse 9. fever 10. itching, skin rash 11. lightheadedness 12. rapid, shallow breathing 13. sweating

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